期刊
JOURNAL OF NATURAL PRODUCTS
卷 67, 期 8, 页码 1400-1402出版社
AMER CHEMICAL SOC
DOI: 10.1021/np049970g
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During the course of our screening program designed to discover novel anticancer and anti-infective agents from marine microorganisms, a strain of Streptomyces aureoverticillatus (NPS001583) isolated from a marine sediment was found to produce a novel macrocyclic lactam with cytotoxicity against various tumor cell lines. Using extensive MS, UV, and NMR spectral analyses, the structure has been established as compound 1, aureoverticillactam, a 22-atom macrocyclic lactam incorporating both triene and tetraene conjugated olefins.
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