期刊
JOURNAL OF BIOCHEMISTRY
卷 136, 期 2, 页码 123-126出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvh117
关键词
apoptosis; liver formation; ALAP kinase; SAPK/JNK; stress
Stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) is activated by many types of cellular stresses and extracellular signals. Recent studies, including the analysis with knockout mice, have led to progress towards understanding the physiological roles of SAPK/JNK activation in embryonic development in addition to immune responses. SAPK/JNK activation plays essential roles in organogenesis during mouse development by regulating cell survival, apoptosis, and proliferation. Two SAPK/JNK activators, SEK1 and MKK7, are required for fetal liver formation and full activation of SAPK/JNK, which responds to various stimuli in an all-or-none manner. This article focuses on physiological roles of SAPK/JNK activation in fetal liver formation and in apoptosis regulation.
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