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NATURE REVIEWS IMMUNOLOGY
卷 4, 期 8, 页码 617-629出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1418
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As their name implies, matrix metalloproteinases are thought to be responsible for the turnover and degradation of the extracellular matrix. However, matrix degradation is neither the sole nor the main function of these proteinases. Indeed, as we discuss here, recent findings indicate that matrix metalloproteinases act on pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
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