期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 15, 期 4, 页码 298-304出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2004.05.005
关键词
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Comparative analysis of the growing number of microbial genome sequences has shown a high plasticity of genomes and several mechanisms for the adaptation of microbial cells to changing environmental conditions have been discovered. By contrast, the underlying metabolic networks of microorganisms are under strict control and relatively rigid, which poses a significant challenge for rational metabolic engineering approaches. Recursive shuffling of whole genomes has recently been demonstrated as an effective new evolutionary whole-cell engineering approach for the rapid improvement of industrially important microbial phenotypes.
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