期刊
JOURNAL OF INFECTIOUS DISEASES
卷 190, 期 3, 页码 430-438出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/422256
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Cytokine and proliferative responses to Necator americanus infection were measured in a treatment-reinfection study of infected subjects from an area of Papua New Guinea where N. americanus is highly endemic. Before treatment, most subjects produced detectable interleukin (IL)-4 (97%), IL-5 (86%), and interferon (IFN)-gamma (64%) in response to adult N. americanus antigen. Pretreatment IFN-gamma responses were negatively associated with hookworm burden, decreasing by 18 pg/mL for each increase of 1000 eggs/gram (epg) (n=75; P<.01). Mean IFN-gamma responses increased significantly after anthelmintic treatment, from 166 to 322 pg/mL (n=42; P<.01 ). The intensity of reinfection was significantly negatively correlated with pretreatment IL-5 responses, decreasing by 551 epg for each 100 pg/mL increase in production of IL-5 (n=51; P<.01). These data indicate that there is a mixed cytokine response in necatoriasis, with worm burden-associated suppression of IFN-g responses to adult N. americanus antigen. Resistance to reinfection is associated with the parasite-specific IL-5 response.
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