In vitro mineralization of surface-modified porous polycaprolactone scaffolds in simulated body fluid

Porous polycaprolactone (PCL) scaffolds were fabricated by combination of porogen-leaching and freeze-drying processes. Ice particulates were used as porogen materials. The porous PCL scaffolds were modified by potassium hydroxide solution with concentration of 1 mol/L at room temperature for 8 h, subsequently biomineralized in simulated body fluid for 2 h and 8 h, respectively. The microstructure and characteristics of the PCL scaffolds were investigated by scanning electron microscope (SEM) and EDS. The results showed (1) PCL scaffolds had high degree of connectivity and different pore sizes. (2) Plate-like apatite was observed on the surface of the scaffolds after being immersed into SBF for 8 h. (c) 2008 Elsevier B. V. All rights reserved.