期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 24, 期 15, 页码 6676-6689出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/mcb.24.15.6676-6689.2004
关键词
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资金
- NCI NIH HHS [R01 CA084309, 5R01 CA 084309-03] Funding Source: Medline
Src family kinases regulate multiple cellular processes including proliferation and oncogenesis. C-terminal Src kinase (Csk) encodes a critical negative regulator of Sire family kinases. We demonstrate that the Drosophila melanogaster Csk ortholog, dCsk, functions as a tumor suppressor: dCsk mutants display organ overgrowth and excess cellular proliferation. Genetic analysis indicates that the dCsk(-/-) overgrowth phenotype results from activation of Src, Jun kinase, and STAT signal transduction pathways. In particular, blockade of STAT function in dCsk mutants severely reduced Sirc-dependent overgrowth and activated apoptosis of mutant tissue. Our data provide in vivo evidence that Src activity requires JNK and STAT function.
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