期刊
PHYSIOLOGY
卷 19, 期 -, 页码 176-182出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00001.2004
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The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in Po-2 are transduced to effect changes in gene expression.
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