期刊
PROTEIN SCIENCE
卷 13, 期 8, 页码 1979-1987出版社
WILEY
DOI: 10.1110/ps.04789804
关键词
apoptosis; caspase; activation and inhibition; IAP; Smac/DIABLO
Caspases, a unique family of cysteine proteases, execute programmed cell death (apoptosis). Caspases exist as inactive zymogens in cells and undergo a cascade of catalytic activation at the onset of apoptosis. The activated caspases are subject to inhibition by the inhibitor-of-apoptosis (IAP) family of proteins. This inhibition can be effectively removed by diverse proteins that share an IAP-binding tetrapeptide motif. Recent structural and biochemical studies have revealed the underlying molecular mechanisms for these processes in mammals and in Drosophila. This paper reviews these latest advances.
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