期刊
DNA REPAIR
卷 3, 期 8-9, 页码 901-908出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2004.03.020
关键词
ATR; DNA replication; checkpoint; single-stranded DNA; RPA
资金
- NCI NIH HHS [R01 CA92245] Funding Source: Medline
The nuclear protein kinase ATR controls S-phase progression in response to DNA damage and replication fork stalling, including damage caused by ultraviolet irradiation, hyperoxia, and replication inhibitors like aphidicolin and hydroxyurea. ATR activation and substrate specificity require the presence of adapter and mediator molecules, ultimately resulting in the downstream inhibition of the S-phase kinases that function to initiate DNA replication at origins of replication. The data reviewed strongly support the hypothesis that ATR is activated in response to persistent RPA-bound single-stranded DNA, a common intermediate of unstressed and damaged DNA replication and metabolism. (C) 2004 Elsevier B.V. All rights reserved.
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