期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 131, 期 1, 页码 93-105出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2004.04.008
关键词
plasmalogens; fatty aldehydes; Schiff bases; gas chromatography-mass spectrometry (GC-MS); oxidative stress; rat brain
The vinyl ether bond of plasmalogens could be among the first target of free radicals attack. Consequently, because of their location in the membranes of cells, plasmalogens represent a first shield against oxidative damages by protecting other macromolecules and are often considered as antioxidant molecules. However, under oxidative conditions their disruption leads to the release of fatty aldehydes. In this paper, we showed using gas chromatography-mass spectrometry (GC-MS) analyses that fatty aldehydes released from plasmalogens after oxidation (UV irradiation and Fe2+ /ascorbate) of cerebral cortex homogenates can generate covalent modifications of endogenous macromolecules such as phosphatidylethanolamine (PE), like the very reactive and toxic malondialdehyde (NIDA) and 4-hydroxynonenal (4-HNE). These newly formed Schiff base adducts could be responsible for deleterious effects on cells thus making the protective role of plasmalogens potentially questionable. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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