期刊
PROTEIN AND PEPTIDE LETTERS
卷 11, 期 4, 页码 377-384出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866043406986
关键词
amyloid-beta; difficult peptide; solid phase peptide synthesis
The phenomenon of difficult sequence has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures are available to minimize or even abolish the negative impact of these sequences during synthesis. These include the use of elevated temperatures and stronger acylating reagents. Amyloid-beta, a fragment of the amyloid precursor protein, contains 40-43 residues and possesses a C-terminal sequence that is particularly resistant to read), solid phase synthesis making it a difficult sequence peptide. This review focuses on approaches to successfully assemble the peptide by both Boc- and Fmoc solid phase synthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据