期刊
MOVEMENT DISORDERS
卷 19, 期 8, 页码 871-884出版社
WILEY
DOI: 10.1002/mds.20115
关键词
Parkinson's disease; falls; gait; freezing; pathophysiology; treatment
资金
- NCRR NIH HHS [RR-13622] Funding Source: Medline
- NIA NIH HHS [AG-08812, AG-14100] Funding Source: Medline
- NICHD NIH HHS [HD-39838] Funding Source: Medline
Falls and freezing of gait are two episodic phenomena that are common in Parkinson's disease. Both symptoms are often incapacitating for affected patients, as the associated physical and psychosocial consequences have a great impact on the patients' quality of life, and survival is diminished. Furthermore, the resultant loss of independence and the treatment costs of injuries add substantially to the health care expenditures associated with Parkinson's disease. In this clinically oriented review, we summarise recent insights into falls and freezing of gait and highlight their similarities, differences, and links. Topics covered include the clinical presentation, recent ideas about the underlying pathophysiology, and the possibilities for treatment. A review of the literature and the current state-of-the-art suggests that clinicians should not feel deterred by the complex nature of falls and freezing of gait; a careful clinical approach may lead to an individually tailored treatment, which can offer at least partial relief for many affected patients. (C) 2004 Movement Disorder Society.
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