期刊
NATURE REVIEWS IMMUNOLOGY
卷 4, 期 8, 页码 583-594出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1412
关键词
-
类别
资金
- Intramural NIH HHS [Z01 AI001019-01, Z01 AI000829-10] Funding Source: Medline
Tissue fibrosis ( scarring) is a leading cause of morbidity and mortality. Current treatments for fibrotic disorders, such as idiopathic pulmonary fibrosis, hepatic fibrosis and systemic sclerosis, target the inflammatory cascade, but they have been widely unsuccessful, largely because the mechanisms that are involved in fibrogenesis are now known to be distinct from those involved in inflammation. Several experimental models have recently been developed to dissect the molecular mechanisms of wound healing and fibrosis. It is hoped that by better understanding the immunological mechanisms that initiate, sustain and suppress the fibrotic process, we will achieve the elusive goal of targeted and effective therapeutics for fibroproliferative diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据