期刊
APPLIED SPECTROSCOPY
卷 63, 期 5, 页码 512-517出版社
SAGE PUBLICATIONS INC
DOI: 10.1366/000370209788347011
关键词
High throughput; Drugs; Human skin; Diffusion; Stratum corneum; Imaging; Attenuated total reflection; Fourier transform infrared spectroscopy; ATR-FT-IR imaging
资金
- EPSRC [EP/D502721, EP/D066859/1]
- EPSRC [EP/D066859/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D066859/1] Funding Source: researchfish
Infrared (IR) spectroscopy has been successfully applied to study the permeation of substances through human skin in a high-throughput manner. The sample of skin was placed on the measuring surface of an attenuated total reflection (ATR) crystal and was divided into several areas. These areas were separated using a specially designed grid created on the surface of the skin and each area was subjected to a different combination of permeant and enhancer. ATR Fourier transform infrared (FT-IR) imaging was applied to measure the permeation of 12 liquid samples through a piece of skin smaller than 5 cm(2). This work demonstrated that, using the ATR-FT-IR imaging method, it is possible to measure and directly compare the transdermal processes of several permeants under identical conditions.
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