期刊
BRITISH JOURNAL OF CANCER
卷 91, 期 3, 页码 537-540出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602027
关键词
survivin; lung cancer; nucleus; tissue array; mitosis; apoptosis
类别
资金
- NCI NIH HHS [P50-CA90949, R01-CA89674, P50 CA090949, R01 CA088076, R01-CA88076, R01 CA089674] Funding Source: Medline
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival ( relative risk: 3.9, P = 0.02). Therefore, survivin may be a biomarker for NSCLC.
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