期刊
TETRAHEDRON
卷 60, 期 33, 页码 6989-6993出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2003.08.083
关键词
C-nor-D-homosteroid; the sponge Terpios hoshinota; nakiterpiosin; nakiterpiosinone; cytotoxicity
Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388). (C) 2004 Elsevier Ltd. All rights reserved.
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