期刊
TETRAHEDRON
卷 60, 期 33, 页码 6981-6988出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2003.08.082
关键词
Acanthella cavernosa; sponge; kalihinol; folate biosynthesis; antibacterial; Philippines
Acanthella spp. sponges have been prolific sources of highly functionalized diterpene antibiotics. Two Acanthella cavernosa sponges were investigated based on the activity of their extracts in a screen designed to detect bacterial folate biosynthesis inhibitors. Bacillus subtilis PY79 strain harboring a lacZ reporter gene fusion to a trimethoprim-responsive promoter (PpanB) was used for the screen. The ability of kalihinols to inhibit bacterial folate biosynthesis was investigated resulting in preliminary structure activity relationships. Eight kalihinol type diterpenes were isolated from two Philippine Acanthella cavernosa specimens including two new 10- and 15-formamido-kalihinol F analogs. (C) 2004 Elsevier Ltd. All rights reserved.
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