期刊
VACCINE
卷 22, 期 23-24, 页码 3182-3186出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.01.053
关键词
intranasal murine parainfluenza virus; paramyxovirus vaccines; Sendai virus
资金
- NCI NIH HHS [CA 21765] Funding Source: Medline
Human parainfluenza virus-type 1 (hPIV-1) is the most common cause of pediatric laryngotracheobronchitis (croup) and results in close to 30,000 US hospitalizations each year [Ped. Inf. Dis. J. 20 (2001) 646]. No effective vaccine is available. We examined murine PIV-1 (Sendai virus, SeV) as a live, xenotropic vaccine for the closely related human PIV-1 in a phase 1, dose escalation study in healthy adults. Intranasal Sendai virus was uniformly well-tolerated and showed evidence of immunogenicity in three of nine vaccinees despite pre-existing, cross-reactive immunity presumably induced by previous exposure to human PIV-1. Results encourage future trials to evaluate the efficacy of Sendai virus in preventing human PIV-1 infection in infants and children. (C) 2004 Elsevier Ltd. All rights reserved.
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