期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 279, 期 33, 页码 34087-34090出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C400236200
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资金
- NCI NIH HHS [CA 90917, CA 78810] Funding Source: Medline
- NHLBI NIH HHS [HL 54131] Funding Source: Medline
- NIA NIH HHS [AG 15393] Funding Source: Medline
Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-) cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.
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