期刊
SCIENCE
卷 305, 期 5686, 页码 1000-1003出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1097071
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资金
- NHLBI NIH HHS [R01 HL67384, R01 HL56416] Funding Source: Medline
- NIDDK NIH HHS [R01 DK53674, T32 DK07519] Funding Source: Medline
Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present evidence that endogenous CD26 expression on donor cells negatively regulates homing and engraftment. By inhibition or deletion of CD26, it was possible to increase greatly the efficiency of transplantation. These results suggest that hematopoietic stem cell engraftment is not absolute, as previously suggested, and indicate that improvement of bone marrow transplant efficiency may be possible in the clinic.
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