期刊
JOURNAL OF IMMUNOLOGY
卷 173, 期 4, 页码 2660-2668出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.4.2660
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- NHLBI NIH HHS [HL55967] Funding Source: Medline
- NIAID NIH HHS [AI34343, AI27243, AI95383, AI47255, AI35726] Funding Source: Medline
MHC class II (MHC-II)-restricted CD4(+) T cells are essential for control of Mycobacterium tuberculosis infection. This report describes the identification and purification of LprG (Rv1411c) as an inhibitor of primary human macrophage MHC-II Ag processing. LprG is a 24-kDa lipoprotein found in the M. tuberculosis cell wall. Prolonged exposure (>16 h) of human macrophages to LprG resulted in marked inhibition of MHC-II Ag processing. Inhibition of MHC-II Ag processing was dependent on TLR-2. Short-term exposure (<6 h) to LprG stimulated TLR-2-dependent TNF-alpha production. Thus, LprG can exploit TLR-2 signaling to inhibit MHC-II Ag processing in human macrophages. Inhibition of MHC-II Ag processing by mycobacterial lipoproteins may allow M. tuberculosis, within infected macrophages, to avoid recognition by CD4(+) T cells.
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