期刊
SCIENCE
卷 305, 期 5687, 页码 1157-1159出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1099755
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资金
- NICHD NIH HHS [HD01426, HD007165, HD42500, HD33438] Funding Source: Medline
Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Genes preferentially expressed in oocytes, including Oct4 and Gdf9, are down-regulated in Nobox(-/-) mice, whereas ubiquitous genes such as Bmp4, Kit, and Bax remain unaffected. Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development.
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