期刊
TETRAHEDRON LETTERS
卷 45, 期 35, 页码 6591-6594出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.07.036
关键词
alkyne; 1,4-addition; rhodium
The metal complex Rh(acac)(CO)(2) in the presence of an eqimolar amount of tris(o-methoxyphenyl)phosphine provides a useful catalyst system for the 1,4-addition of alkynes to unsubstituted vinyl ketones. Best yields are obtained when the transformation is performed in benzene at reflux with an excess of vinyl ketone. Both aryl and alkyl substituted alkynes participate in the reaction. Primary alcohols and alkyl chlorides are well tolerated under these reaction conditions. The reaction also proceeds in aqueous solvent mixtures, unlike most organometallic addition reactions. (C) 2004 Elsevier Ltd. All rights reserved.
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