期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 126, 期 33, 页码 10313-10318出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja047190o
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资金
- NIGMS NIH HHS [GM 35249] Funding Source: Medline
A formal total synthesis of oximidine II has been achieved, employing a Suzuki-type coupling approach to construct the highly strained, polyunsaturated 12-membered macrolactone. To achieve this goal, benefit was derived from the stability of potassium alkenyltrifluoroborates to establish conditions for the macrocyclization. The stereocontrolled formation of the cis-1,2-diol subunit was accomplished using a diastereoselective, reagent controlled addition to a chiral aldehyde utilizing the Carreira protocol. Advantage was taken of the Snieckus hydroborating reagent to gain access to the key trifluoroborate needed for the macrocyclization.
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