期刊
NEUROREPORT
卷 15, 期 12, 页码 1857-1860出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200408260-00004
关键词
activity; DAMGO; feeding; food reward; muscimol; nucleus accumbens; palatability
资金
- NIDA NIH HHS [DA09311, F32 DA14751] Funding Source: Medline
Endogenous opioid peptides within the nucleus accumbens are thought to mediate the hedonic aspects of food intake, particularly foods such as fat and sugar. In view of evidence that the amygdala also regulates positive affect, we hypothesized this brain region participates in the control of opioid-mediated food intake. The robust increase in the intake of fat following intra-accumbens administration of the p-opioid agonist D-Ala2,Nme-Phe4,Glyol5-enkephalin (DAMGO) was completely blocked by concurrent temporary inactivation (muscimol, GABA(A) agonist) of either the basolateral or central nucleus of the amygdala. In summary, we demonstrate that amygdala inactivation prevents the intra-accumbens opioid induced binge eating of fat, possibly through reducing the hedonic properties of high-fat palatable food.
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