期刊
NEUROSCIENCE LETTERS
卷 367, 期 1, 页码 1-5出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.04.056
关键词
long-term potentiation (LTP); hippocampus; depotentiation; NMDA; mGlu; development; synaptic plasticity; homosynaptic
Low-frequency stimulation (LFS) is used to induce long-term depression (LTD) and depotentiation at rodent CA3-CA1 hippocampal synapses. The relationship between the efficacy of LFS induction and postnatal age remains to be clearly defined in rat and had not been studied in mouse. The data presented here show that in acute mouse hippocampal slices LFS-induced LTD and depotentiation at CA3-CA1 synapses are: synapse specific; NMDA receptor-dependent; and metabotropic glutamate (mGlu) receptor type I/II independent. Furthermore LFS-induced LTD is highly age-dependent whilst long-term potentiation (LTP) and depotentiation are not. In slices from very young mice (P6-9) LFS induced a robust and stable LTD (-31.1 +/-5.9%, n = 8, P < 0.01) of CA1 field excitatory post-synaptic potentials (fEPSPs), measured 55-60min after conditioning. LFS also induced LTD in slices from mice aged P10-13 and P14-17 (-16.0 +/- 3.0%, n = 35, P < 0.001 and -17.9 +/- 5.5%, n = 12, P < 0.01, respectively). However, LTD was not expressed in slices from animals aged P18-21 (-7.0 +/- 4.1%, n = 16, P > 0.05) or older. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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