Association study of PICKI rs3952 polymorphism and schizophrenia

Protein interacting with C-kinase-I (PICKI) plays an important role in the targeting and clustering of neuronal receptors and amine transporters. The PICKI gene may play a role in conferring susceptibility to schizophrenia as it has been mapped to chromosome 22q13.1, a region thought to contain a gene for schizophrenia. We tested the hypothesis that an allelic variant of the PICKI gene was associated with a diagnosis of schizophrenia. The PICKI rs3952 polymorphism was genotyped in 225 schizophrenia and 260 controls. Results demonstrated that the PICKI rs3952 genotype and allele distribution was significantly different between the two groups. The positive association suggests that the PICKI gene may play a role in the pathogenesis of schizophrenia.