期刊
BRAIN RESEARCH
卷 1018, 期 2, 页码 247-256出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.05.080
关键词
diaphragm; phrenic motoneuron; reticular formation; vestibular system
资金
- NEI NIH HHS [EY08098] Funding Source: Medline
- NIDCD NIH HHS [DC05205, R01 DC003732, R01 DC003732-07, R01 DC03732] Funding Source: Medline
Prior studies have shown that the vestibular system contributes to adjusting respiratory muscle activity during changes in posture, and have suggested that portions of the medial medullary reticular formation (MRF) participate in generating vestibulo-respiratory responses. However, there was previously no direct evidence to demonstrate that cells in the MIZE relay vestibular signals monosynaptically to respiratory motoneurons. The present study tested the hypothesis that the firing of MRF neurons whose axons could be antidromically activated from the vicinity of diaphragm motoneurons was modulated by whole-body rotations in vertical planes that stimulated vestibular receptors, as well as by electrical current pulses delivered to the vestibular nerve. In total, 171 MRF neurons that projected to the C-5-C-6 ventral horn were studied; they had a conduction velocity of 34 +/- 15 (standard deviation) m/sec. Most (135/171 or 79%) of these MRF neurons lacked spontaneous firing. Of the subpopulation of units with spontaneous discharges, only 3 of 20 cells responded to vertical rotations up to 10degrees in amplitude, whereas the activity of 8 of 14 neurons was affected by electrical stimulation of the vestibular nerve. These data support the hypothesis that the MRF participates in generating vestibulo-respiratory responses, but also suggest that some neurons in this region have other functions. (C) 2004 Elsevier B.V. All rights reserved.
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