期刊
FEBS LETTERS
卷 573, 期 1-3, 页码 26-30出版社
WILEY-BLACKWELL
DOI: 10.1016/j.febslet.2004.07.048
关键词
phospholipase C; thrombosis; GPIb; von Willebrand factor; signaling
资金
- NHLBI NIH HHS [HL-44612] Funding Source: Medline
Though phospholipase C PLCgamma2 is known to play an important role in platelet activation by collagen and fibrinogen its importance in GPIb-mediated platelet activation is less well understood. To better understand the role of PLCgamma2 in GPIbmediated adhesion and thrombus formation, we examined the ability of wild-type and PLCgamma2- deficient murine platelets to spread on immobilized von Willebrand factor (VWF) under static conditions, and to attach to and form thrombi on VWF under conditions of arterial shear. While absence of PLCgamma2 had only a minimal effect on platelet adhesion to immobilized VWF, its absence impaired spreading and profoundly affected thrombus growth and stability on VWF. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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