期刊
PEDIATRICS
卷 114, 期 3, 页码 E373-E377出版社
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2004-0196
关键词
prenatal glucocorticoids; respiratory distress syndrome; blood pressure; long-term follow-up
类别
Objective. To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. Design. Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. Setting. National Women's Hospital ( Auckland, New Zealand). Participants. Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS. Intervention. Mothers received 2 doses of betamethasone ( 12 mg) or placebo, administered through intramuscular injection, 24 hours apart. Main Outcome Measures. Systolic and diastolic blood pressure at 6 years of age. Results. Children exposed prenatally to betamethasone ( n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo ( n = 102) ( mean difference: systolic: - 1.6 mm Hg; 95% confidence interval: - 4.1 to 0.8 mm Hg; diastolic: - 0.3 mm Hg; 95% confidence interval: - 2.5 to 1.8 mm Hg). Conclusion. Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age.
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