期刊
ORAL ONCOLOGY
卷 40, 期 8, 页码 811-814出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2004.02.003
关键词
bone marrow transplantation; oral graft-versus-host disease; Tacrolimus
Oral involvement of chronic graft-versus-host disease (GvHD) is a most distressing and disabling complication of hematopoietic cell transplantation, for which systemic immunosuppression as welt as topical corticosteroid treatment may offer only limited symptomatic relief. Here we report encouraging preliminary results with the application of tacrolimus (FK-506) as a 0.1% ointment in three patients with severe oral chronic GvHD, heavily pretreated without success, who experienced rapid, consistent, complete or at least marked, subjective and objective improvement with topical tacrolimus. (C) 2004 Elsevier Ltd. All rights reserved.
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