期刊
APPLIED RADIATION AND ISOTOPES
卷 88, 期 -, 页码 12-15出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2014.04.007
关键词
Head and neck cancer; Recurrent SCC; Locally advanced non-SCC; BNCT
类别
资金
- JSPS [24592611]
- Grants-in-Aid for Scientific Research [25461901, 24592611] Funding Source: KAKEN
The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-squamous cell carcinoma without malignant melanoma (non-SCC) of the head and neck. Currently, clinical trials of BNCT for head and neck cancers are being conducted in some institutes to verify its the effectiveness. BNCT was performed in 10 patients with recurrent SCC, 7 patients with recurrent non-SCC and 3 patients with newly diagnosed non-SCC in our university between October 2003 and September 2007. Eleven patients showed complete remission and 7 patients showed partial remission of irradiated site. The effective rate [(CR+PR)/total cases] was 90%. No severe acute or chronic normal-tissue reactions were observed in any patients. BNCT is effective and safe in the patients with recurrent SCC and locally advanced non-SCC (C) 2014 Elsevier Ltd. All rights reserved.
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