期刊
EXPERIMENTAL GERONTOLOGY
卷 39, 期 9, 页码 1285-1294出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2004.06.013
关键词
aging; intestinal immunity; reovirus; IgA antibodies; cytotoxic T-lymphocytes
资金
- NCRR NIH HHS [P20-RR16440] Funding Source: Medline
- NIAID NIH HHS [R01-AI034544] Funding Source: Medline
Systemic immunity is progressively impaired in aging, predisposing to morbidity and mortality from neoplasia and infectious disease. However, the effect of aging on mucosal immunity is controversial. To assess intestinal immunity in aging, young and aged mice were orally exposed to reovirus or cholera toxin (CT) and specific antibody and reovirus-specific cytotoxic T-cell (CTL) responses were assessed. As previously reported, aged mice immunized orally with CT mounted diminished intestinal IgA responses to CT compared to young mice. In contrast. aged mice yielded two to three-fold more reovirus-specific IgA-producing cells in the Peyers's patches (PP) compared to young mice, and higher titers of reovirus-specific IgA in fragment culture supernatants. Cytotoxicity and CTL frequencies from aged mice were not different from those of young mice. Together, these results suggest a diminished potential for systemic and intestinal immunity to orally applied protein antigens in aging, but an intact ability to respond to intestinal virus infection. Infection with a replicating virus may induce inflammatory mediators and innate immune factors that potentiate the priming of mucosal immunity; overcoming aging related deficits otherwise observed following oral immunization with non-replicating antigens, and suggests the importance of antigen replication to antigen-specific immunotherapy strategies in the elderly. (C) 2004 Elsevier Inc. All rights reserved.
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