期刊
APPLIED RADIATION AND ISOTOPES
卷 82, 期 -, 页码 75-80出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2013.07.023
关键词
Loop method; Grignard reaction; Carbon-11; [C-11]-(+)-PHNO; [carbonyl-C-11] WAY 100635
类别
资金
- Austrian Science Fund (FWF) [P23585]
- Austrian Science Fund (FWF) [P 23585] Funding Source: researchfish
- Austrian Science Fund (FWF) [P23585] Funding Source: Austrian Science Fund (FWF)
Aim of this work was the implementation of a generalized in-loop synthesis for C-11-carboxylations and subsequent C-11-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-C-11] WAY-100635 and, for the first time, [C-11]-(+)-PHNO. Its general applicability could be demonstrated and both [carbonyl-C-11]WAY-100635 and [C-11]-(+)-PHNO were prepared with high reliability and satisfying outcome. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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