期刊
APPLIED RADIATION AND ISOTOPES
卷 70, 期 3, 页码 489-497出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.10.015
关键词
Fluorine-18; TRACERlab FX-FN; TSPO 18 kDa; [F-18]DPA-714; [F-18]FEDAA1106; [F-18]PBR111
类别
资金
- EC-FP6-project DiMI [LSHB-CT-2005-512146]
- EMIL [LSH-2004-503569]
Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [F-18]DPA-714, [F-18]PBR111 and [F-18]FEDAA1106, three promising radiotracers for Tspo 18 kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [F-18]DPA-714. (C) 2011 Elsevier Ltd. All rights reserved.
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