期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 9, 期 -, 页码 2227-2244出版社
IMR PRESS
DOI: 10.2741/1393
关键词
cell adhesion molecule; NCAM; signaling; homophilic binding; heterophilic ligands; review
Neural cell adhesion molecule ( NCAM) was originally characterised as a homophilic cell adhesion molecule (CAM) abundantly expressed in the nervous system. However, the last decade of research has challenged the traditional view and defined novel roles for NCAM. NCAM is now considered a signaling receptor that responds to both homophilic and heterophilic cues, as well as a mediator of cell-cell adhesion. This review describes NCAM function at the molecular level. We discuss recent models for extracellular ligand-interactions of NCAM, and the intracellular signaling cascade that follows to define cellular outcomes such as neurite outgrowth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据