期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 51, 期 3, 页码 191-204出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2004.04.006
关键词
molecular imaging; functional imaging; herpes simplex virus type 1 thymidine kinase; dopamine D2 receptor; PET; MicroPET; gene therapy; reporter gene
资金
- NCI NIH HHS [P50 CA88306, R01 CA84572] Funding Source: Medline
Positron-emission tomography (PET) has been used extensively in the clinic for cancer diagnosis, for staging and for monitoring of therapeutic efficacy. PET has not, however, been used extensively in contemporary animal cancer models. Until recently, appropriate instrumentation was not available and the expertise and knowledge necessary to perform PET analyses in murine models has not been widespread. The fabrication of microPET instruments with appropriate resolution for murine experiments has lead to the establishment of non-invasive techniques for functional imaging. The development of PET reporter genes whose activity can be monitored in living animals, based on the reporter gene-dependent sequestration of positron-emitting PET reporter probes, has lead to innovative analyses of gene expression in transgenic animals, to methods to monitor the location, magnitude and duration of expression for gene therapy vectors and to the ability to non-invasively track the targeting, viability and expansion of cellular therapeutics. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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