期刊
EUROPEAN JOURNAL OF CANCER
卷 40, 期 14, 页码 2159-2164出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ejca.2004.06.011
关键词
plasma TIMP-1; colorectal adenomas; colorectal cancer; diagnosis
类别
Colorectal cancer patients have increased plasma levels of tissue inhibitor of metalloproteinases-1 (TIMP-1). However, it remains unresolved whether colorectal adenomas are associated with increased plasma TIMP-1. Plasma TIMP-1 levels were determined using an immunoassay in 121 patients prospectively enrolled from surveillance colonoscopy programmes. TIMP-1 levels were correlated to various clinicopathological parameters. No significant associations were found between plasma TIMP-1, and size, macro- or microscopic morphology or grade of dysplasia of the adenomas. No significant differences in TIMP-1 levels were found between patients with adenomas (n=36), hyperplastic polyps (n=12) or no pathology (n=68) of the large intestine. However, patients with colonic (n=3) or rectal (n=2) adenocarcinomas had significantly increased TIMP-1 levels (P=0.02). The present study demonstrates that measurement of plasma TIMP-1 cannot be used for the identification of adenomatous or hyperplastic polyps of the large intestine. (C) 2004 Elsevier Ltd. All rights reserved.
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