期刊
JOURNAL OF CELL SCIENCE
卷 117, 期 19, 页码 4343-4354出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.01392
关键词
small GTPases; protein kinases; signal transduction
类别
p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. With the notable exception of plants, nearly all eukaryotes encode one or more Pak genes, indicating an ancient origin and important function for this family of enzymes. Genetic approaches in many different experimental systems, ranging from yeast to mice, are beginning to decipher the different functions of Paks. Although some of these functions are unique to a given organism, certain common themes have emerged, such as the activation of mitogen-activated protein kinase (MAPK) cascades and the regulation of cytoskeletal structure through effects on the actin and tubulin cytoskeletons.
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