期刊
APPLIED RADIATION AND ISOTOPES
卷 68, 期 2, 页码 293-296出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2009.10.005
关键词
Electrophylic fluorination; F-18-labeling; Catalysis; EF5
类别
资金
- NIH [CA87645]
Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of F-18 positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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