期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 75, 期 3, 页码 504-507出版社
CELL PRESS
DOI: 10.1086/423790
关键词
-
资金
- NCRR NIH HHS [M01 RR000052, M01-RR00052] Funding Source: Medline
- NIAMS NIH HHS [R01 AR043727, R01 AR32274, R01 AR43727] Funding Source: Medline
We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the results with data generated from 1,961 white control individuals. The R620W SNP was associated with SLE (genotypic P=.00009), with estimated minor (T) allele frequencies of 12.67% in SLE cases and 8.64% in controls. A single copy of the T allele (W620) increases risk of SLE (odds ratio [OR]=1.37; 95% confidence interval [CI] 1.07-1.75), and two copies of the allele more than double this risk (OR=4.37; 95% CI 1.98-9.65). Together with recent evidence showing association of this SNP with type 1 diabetes and rheumatoid arthritis, these data provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据