A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: Radiosynthesis and initial small-animal PET studies

The CGS 27023A derivative (R)-2-(N-((6-fluoropyridin-3-yl)methyl)-4-methoxyphenyl-sulphonamido)-N-hydroxy-3-methylbutanamide la was identified as a very potent matrix metalloproteinase inhibitor. Here, we describe a one-step radiosynthesis of the target compound [F-18]1a. The syntheses of [18F]1a resulted in a radiochemical yield of 12.1 +/- 5.9% (decay-corrected), a radiochemical purity of 98.8 +/- 0.6%, and a specific activity of 39 +/- 27GBq/mu mol at the end of synthesis within 160 +/- 18min from the end of radionuclide production (n = 5). Initial small-animal PET studies in wild-type mice (C57/BL6) showed no unfavourable tissue accumulation of [F-18]1a. (C) 2009 Elsevier Ltd. All rights reserved.