期刊
FREE RADICAL RESEARCH
卷 38, 期 9, 页码 1021-1026出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760410001717327
关键词
yeast; Saccharomyces cerevisiae; superoxide dismutase; free radicals; oxidative stress; aging
Yeast (Saccharomyces cerevisiae) mutants lacking CuZn-superoxide dismutase (CuZnSOD) are hypersensitive to oxygen and have significantly decreased replicative life span. Both these defects can be ameliorated by exogenous ascorbate. The effect of ascorbate on life span is complicated by auto-oxidation of its compound in the medium. If negative effects of auto-oxidation are prevented by exchange of the medium, ascorbate prolongs not only mean but also maximal replicative life span of the yeast in the atmosphere of air and of pure oxygen. These results demonstrate that life span shortening due to the lack of a vital antioxidant enzyme can be ameliorated by a low-molecular weight antioxidant.
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