期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 6, 期 5, 页码 822-827出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc049916i
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The solid-phase synthesis of a library of di-, tri-, and tetrasubstituted ureas is described. In this approach, an array of polymer-bound carbamates was synthesized. These polymer-bound primary and secondary amine carbamates were then treated under smart diversity-building cleavage conditions using a series of aluminum amide complexes to form the corresponding urea cleavage products. The crude cleavage products from this study were isolated in excellent yield and purity. To show the applicability of this strategy, a series of biaryl ureas were synthesized using sequential solid-phase Suzuki coupling and urea formation reactions.
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