期刊
APPLIED RADIATION AND ISOTOPES
卷 66, 期 10, 页码 1341-1345出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2008.04.011
关键词
radioactive chlorine; positron emission tomography; [*Cl]chlorination; [*Cl]chloroamine-T; diphenyliodonium salt
The aim of this study was how to introduce radioactive chlorine (*Cl) isotope into a benzene ring to afford *Cl-labeled chlorobenzene ([*Cl]1). Using tributylphenylstannyl compound (2) as a starting material, we determined two routes for introducing *Cl into the benzene ring: reaction of [*Cl]Cl- with 2 in the presence of chloramine-T and nucleophilic reaction of [*Cl]Cl- with diphenyliodonium tosylate (3). The two routes provide suitable tools to prepare [*Cl]1 without electron-abstracting group in the benzene ring. (c) 2008 Elsevier Ltd. All rights reserved.
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