期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 294, 期 2-3, 页码 203-212出版社
URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2004.06.015
关键词
foreign bode infection; quorum sensing; alternative sigma factor; biofilm formation; adhesion; stress response
Biomaterial-associated infections, most frequently caused by Staphylococcus epidermidis and Staphylococcus aureus, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the pathogenesis of biomaterial-associated staphylococcal infections is the formation of adherent, multilayered bacterial biofilms. In this review, recent insights regarding factors functional in biofilm formation of S. epidermidis, their role in pathogenesis, and regulation of their expression are presented. Similarly, in S. aureus the biofilm mode of growth affects gene expression and the overall metabolic status. Experimental approaches for analysis of differential expression of genes involved in these adaptive responses and evolving patterns of gene expression are discussed. (C) 2004 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据