期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 15, 期 6, 页码 447-450出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001721-200408000-00002
关键词
platelet; aggregation; garlic; ajoene; antithrombotic; aromatic disulfides
类别
Several sulfur-containing compounds, isolated from garlic, have been implicated as highly active antithrombotic agents. We have prepared 10 new aromatic disulfides and an aromatic thiosulfonate in order to determine the in vitro response of human platelets to dosages of these compounds. The poor biological activity of PhSSCH3 Was enhanced by the introduction of, inter alia, a nitro group onto the aromatic ring. The nitro group increased potency by activating the disulfide linkage. Anti-platelet aggregation activity was also enhanced by increasing the lipophilicity of one test compound. The ability of an aromatic disulfide to inhibit platelet aggregation can be enhanced by appending an electron-withdrawing group to the aromatic ring. The results presented establish that the aromatic thiosulfonate is a very effective inhibitor of platelet aggregation.
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