期刊
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
卷 38, 期 5, 页码 558-565出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/apnm-2012-0230
关键词
exhaustive exercise; oxidative stress; purple grape juice; polyphenols; antioxidant capacity; neuroprotection
资金
- FAPERGS (Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- FINEP (Rede Instituto Brasileiro de Neurociencia (IBN-Net) [01.06.0842-00]
- Econatura Produtos Ecologicos e Naturais LTDA
This study aimed to assess the potential protective effect of organic purple grape juice (PGJ) on oxidative stress produced by an exhaustive exercise bout in rats. To test this hypothesis, rats were acutely treated with organic PGJ (Vitis labrusca) and subsequently submitted to an exhaustive exercise bout. Parameters of oxidative stress, such as thiobarbituric acid reactive species (TBARS) levels, 2',7',-dichlorofluoresceindiacetate (DCFH-DA) oxidation, and nonprotein sulfhydryl levels (NP-SH) in the brain, skeletal muscle, and blood, were evaluated. Enzyme activity of Na+,K+-ATPase, Ca2+-ATPase, and delta-aminolevulinate dehydratase (delta-ALA-D) in the brain, skeletal muscle, and blood were also assayed. Statistical analysis showed that the exhaustive exercise bout increased TBARS levels and DCFH-DA oxidation, and decreased NP-SH levels in rat tissue. Ca2+-ATPase activity was increased in groups exposed to both exercise and PGJ treatment. The results indicate that organic PGJ intake was able to protect against the oxidative damage caused by an exhaustive exercise bout in different rat tissues.
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