期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 191, 期 3, 页码 733-740出版社
MOSBY, INC
DOI: 10.1016/j.ajog.2004.03.035
关键词
ovarian cancer; endometriosis; estrogen; oral contraceptive
资金
- NCI NIH HHS [R01CA61095, R01-CA-58598, N01-CN-67001, R01 CA76016, R01-CA61093, K07-CA80668] Funding Source: Medline
Objective: Women with endometriosis may be at an increased risk of ovarian cancer. It is not known whether reproductive factors that reduce the risk of ovarian cancer in general also reduce risk in women with endometriosis. We investigated whether the odds ratios for ovarian cancer that were associated with oral contraceptive use, childbearing, hysterectomy, and tubal ligation differ among women with and without endometriosis. Study design: We pooled information on the self-reported history of endometriosis from 4 population-based case-controlled studies of incident epithelial ovarian cancer, comprising 2098 cases and 2953 control subjects. We obtained data on oral contraceptive use, childbearing, breastfeeding, gynecologic surgical procedures, and other reproductive factors on each woman. Multivariable unconditional logistic regression was used to calculate odds ratios and 95% CI for ovarian cancer among women with endoinetriosis compared with women without endometriosis. Similar methods were used to assess the frequencies of risk factors among women with and without endometriosis. Adjustments were made for age, parity, oral contraceptive use, tubal ligation, family history of ovarian cancer, and study site. Results: Women with endometriosis were at an increased risk of ovarian cancer (odds ratio, 1.32; 95% Cl, 1.06-1.65). Using oral contraceptives, hearing children, and having a tubal ligation or hysterectomy were associated with a similar reduction in the odds ratios for ovarian cancer among women with and without endometriosis. In particular, the use of oral contraceptives for > 10 years was associated with a substantial reduction in risk among women with endometriosis (odds ratio, 0.21; 95% CI, 0.08-0.58). Conclusion: Women with endometriosis are at an increased risk of epithelial ovarian cancer. Long-term oral contraceptive use may provide substantial protection against the disease in this high-risk population. (C) 2004 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据